Premedications are antibiotics that are recommended for patients with heart and other medical conditions. And YES, you need to take it One Hour before your procedure and even your consultation. This is a necessary precaution to prevent possible infection. Please take your premeds! Being on antibiotics for 2-3 days already does not count as taking premedication. The dosage for regular antibiotics are often too low to be considered an effective premedication. For example, a patient taking 500mg of Amoxicillin 4 times a day for 3 days still has to take 2000mg of Amoxicillin 1 hour before their consultation and/or procedure. If you still have more questions, please call our office.